Category Archives: Lupus

The Dirty Little Lupus Secret

dirtyThere’s an easy explanation for why lupus and autoimmune disorders have skyrocketed in the United States—tripling between 1950 and 1992 (Uramoto et al 1999)—but we have to dive into some genetics first.

Women have two X chromosomes, but one stays inactive and is called Xi. Xi is packed away in a tight suitcase of facultative heterochromatin, where it mostly sleeps for the lifetime of the woman.

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